The development of hypocretin (OREXIN) deficiency in hypocretin/ataxin-3 transgenic rats
نویسندگان
چکیده
منابع مشابه
The Role of Hypocretin/Orexin in Stress-Induced Analgesia
Orexin is produced exclusively in the lateral hypothalamus, where it is known to be involved in pain modulation through brain stem. Due to the important role of this peptide in functions such as eating, sleeping and awaking, addiction, it attracted the attention of researchers in medical sciences specially neuroscientists. These hypothalamic peptides play a critical role in arousal in s...
متن کاملHypocretin (orexin) deficiency in narcolepsy and primary hypersomnia.
The discovery that hypocretins are involved in narcolepsy, a disorder associated with excessive daytime sleepiness, cataplexy, and unusually rapid transitions to rapid eye movement sleep, opens a new field of investigation in the area of disorders of sleep and activation. Hypocretin-1 (hcrt-1) and hypocretin-2 (hcrt-2) (also called orexin-A and orexin-B) are newly discovered neuropeptides proce...
متن کاملHLA DQB1*06:02 negative narcolepsy with hypocretin/orexin deficiency.
STUDY OBJECTIVES To identify rare allelic variants and HLA alleles in narcolepsy patients with hypocretin (orexin, HCRT) deficiency but lacking DQB1*06:02. SETTINGS China (Peking University People's Hospital), Czech Republic (Charles University), Denmark (Golstrup Hospital), Italy (University of Bologna), Korea (Catholic University), and USA (Stanford University). DESIGN CSF hypocretin-1, D...
متن کاملOverview of orexin/hypocretin system.
A series of recent studies has established the orexin/hypocretin system as a critical regulator of sleep/wake states. Its deficiency results in the sleep disorder narcolepsy in humans, dogs, and rodents. These findings have brought about the possibility of novel therapies for sleep disorders including narcolepsy and insomnia. Moreover, accumulating evidence indicates that the orexin/hypocretin ...
متن کاملNormal Role of Hypocretin/Orexin
There is now no doubt that hypocretin/orexin (Hcrt) deficiency is the cause of most narcolepsy in humans (1,2). It is also clear that mutations of the Hcrt system cause genetic narcolepsy in several animal species (3,4). Narcolepsy in these Hcrt deficiency situations is characterized by sleepiness during the normally active period and losses of muscle tone during waking periods called cataplexy...
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ژورنال
عنوان ژورنال: Neuroscience
سال: 2007
ISSN: 0306-4522
DOI: 10.1016/j.neuroscience.2007.05.029